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CLC bio heads pan-European genomics project

CLC bio will be leading a pan- European comparative genomics project, COGANGS (Comparative Genomics and Next Generation Sequencing), to develop a software suite where up to 1,000 genomes can be used as knowledge input in gene regulation analysis.

The project is sponsored by the European Union with €1.6 million, and in addition to CLC bio involves BIOBASE, Germany; deCODE genetics, Iceland; Alfréd Rényi Institute of Mathematics, Hungary; BioRainbow, Russia; and the University of Oxford, United Kingdom.

‘It’s highly interesting for us to

participate in this project as we can potentially unlock a lot of information in the vast collection of human DNA samples we already have, once this project enables us to do large-scale comparative genomics

analyses. We will apply both the initial prototype and the fi nal software package for the analysis of regions that have been identifi ed to have strong disease associations in the human genome,’ said Gísli Másson, director of bioinformatics at deCODE Genetics.

The COGANGS project will develop

a software suite where a large number of genomes can be used as knowledge input in gene regulation analysis, like analysis of which factors infl uence gene regulation, how much impact they have on gene regulation, how they can be identifi ed in the genome of interest, how different gene regulation factors infl uence each other, and how they work in combination. Such software will be able to provide completely new knowledge, and will have tremendous value to life science researchers globally.

Genedata Expressionist Refiner MS aids agribioscience research

Australia’s Department of Primary Industries (DPI), located in Victoria, has selected Genedata Expressionist Refi ner MS for mass spectrometry for use in its agribioscience research. With advanced visualisation capabilities, Refi ner MS will help DPI scientists analyse huge proteomics and metabolomics datasets at any stage of data processing. ‘We focus on the systems biology of agriscience, and Genedata Expressionist helps us make sense of all the raw data made available to us through proteomics and metabolomics,’ said Ben Cocks, research director for the Biosciences Research Division. ‘With Refi ner MS we’re analysing hundreds of one-gigabyte LC/MS fi les.’


Refi ner MS is a module within the Genedata Expressionist enterprise system for biomarker discovery and molecular profi ling. The system is a single-point- of-access for experimental, proprietary and public data, including sample information, raw and pre-processed data, and analysis results with reports and documentation. Functionality can be extended along the R&D workfl ow with additional Refi ner modules, as well as Genedata Analyst for sample-centric data organisation, statistical analysis, biological interpretation, prediction and decision support.


AIT Bioscience, a bioanalytical contract research organisation (CRO) supporting preclinical trials and all phases of clinical drug development, has selected IDBS to deliver a fully electronic laboratory notebook system to record, organise and archive the bioanalytical data provided to its pharmaceutical and biotechnology clients. AIT Bioscience has implemented a totally paperless system which addresses the challenging commercial and regulatory requirements faced by CROs; specifi cally to deliver quality-assured methods and regulated study results and reports to their customers at a competitive pace. E-WorkBook enables the

organisation to dramatically improve its delivery time for study reports, and it is now able to release its fi nal study report one to two weeks after the last sample has been received, as opposed to between four and eight weeks using hybrid or fully paper systems. Manually validating data from a paper record or spreadsheet involves signifi cant labour costs, using staff who are technically able to understand the complexities of

the experiments and how the data contributes to the fi nal reports. E-WorkBook’s validated templates also provide secure links between the original data and any fi nal calculations for ease of audit. This enables AIT Bioscience to assure customers that their data is recorded just as securely as a traditional paper record, but with the added advantages of rapid validation of the data entries against pre-established business and scientifi c rules. Additionally, data can be segregated by study, sponsor and regulatory level to ensure confi dentiality and control. Linking with Watson LIMS, E-WorkBook also manages laboratory process control, business workfl ows and equipment records, alongside instrumental data. E-WorkBook Suite supports Quality by Design and audit by exception guidelines. It further enables review and verifi cation of information in real time and guarantees that the data can be accurately reconstructed months or years later. Scientists can now capture, verify and review data from the entire bioanalytical process in one systematic, compliant environment.

Pittcon 2011 conferee networking sessions announced

The Pittcon Networking Committee has announced the topics of the conferee networking sessions for Pittcon 2011, which will take place between 13 and 18 March 2011 at the Georgia World Congress Center in Atlanta, Georgia. Beginning on Sunday 13 March and continuing until Wednesday 16 March, session topics include chromatography, data analysis, environmental, spectroscopy, life science and laboratory management. There will be a total of 28 total sessions; 20 of which are new, with

eight being repeated from last year’s programme, with four evening sessions scheduled from 16:30 to 18:30 on 14 and 15 March.

Session titles include ‘Non Invasive Biomedical Analysis’,’ Laboratory Standardisation: Applications, Benefi ts and Challenges’, and ‘What is the Fast Approach to get a LIMS Validated, Up and Running?’. Conferee networking sessions are open to registered conferees; however, seating is limited and will be available on a fi rst-come, fi rst-served basis.

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