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These price rises have been the impetus behind the development of cheaper alternatives to the barbiturates. In 2014, ‘activist doctors’ in Washington State were the first to develop a new lethal ‘3-Drug Protocol’. Although effective in bringing about death, some peo- ple experienced swallowing difficulties and so the research con- tinued. In late 2016, an improved ‘4-Drug protocol’(also known as ‘DDMP’) was trialed. More recent improvements have seen the DDMP2, D-DMP2 and a D-DMA mixtures emerge. In 2020, the addition of phenobarb (Ph) to form a new 5-drug D-DMAPh mix was created. These drug combinations are comprised of read- ily-available pharmaceuticals that can be taken orally without medical assistance. All provide an effective, elective DIY death. This Chapter provides details of these newly-developed mixtures.