This page contains a Flash digital edition of a book.
« SECTION TITLE Titratable Dosage Transdermal


Delivery System; C. Wright IV; U.S. Patent # 9,289,397, March 22. 2016.


The current transdermal patches deliver actives at fi xed dosages. The fl ux or the rate of release and subsequent absorption of drug depends upon an individual patient. There is high inter-subject variability. It means, some patients will get higher doses at faster rate whereas some others will get low doses at a slower fl ux. The current invention provides a transdermal delivery system that can deliver titratable dosage of therapeutic agent. It provides plurality of patches with diff erent dose strengths. Based on the fl ux, patients can apply diff erent number of patches. Each patch unit comprises (1) a backing layer having one or more borders, (2) a drug layer, (3) an impermeable layer in contact with the drug layer, in which the impermeable layer is between the backing layer and the drug layer, and (4) an adhesive layer; the drug layer comprises a polymer, levulinic acid and buprenorphine.


Gastric Retentive Dosage Forms for Extended Release of Acamprosate into the Upper


Gastrointestinal Tract; B. Berner and C. Chen; U.S. Patent # 9,301,934; April 5, 2016.


Acamprosate is a synthetic analog of .gamma.-amino butyric acid (GABA) and is used as an adjunct for treatment of alcohol dependence. As alcohol inhibits the activity of N-methyl-D- aspartate receptors (NMDARs), chronic alcohol consumption leads to the upregulation of these receptors. Sudden alcohol abstinence results in excessive activation of NMDARs, leading to symptoms such as delirium tremens and excitotoxic neuronal death. Acamprosate reduces this eff ect in vivo. Acamprosate exhibits poor absorption in the intestine after oral dosing. In this invention, a gastric retained extended release oral dosage form comprising a dose of acamprosate dispersed in a polymer matrix comprising at least one hydrophilic polymer is provided. Upon administration, the polymer matrix swells upon imbibition of fl uid to a size suffi cient such that the dosage form is retained in the stomach of a subject in a fed mode and the dose of acamprosate is released over an extended period of time.


Drug Coated Balloon With In-Situ Formed Drug


Containing Microspheres; S.D. Pacetti and J.J. Stankus; U.S. Patent # 9,295,663, March 29, 2016.


The current invention describes methods of forming a coating that involves the in-situ formation of drug microspheres. The coating is then applied to a medical device, such as a catheter balloon or a stent. Using catheter techniques originally developed for heart exploration, infl atable balloons were employed to re-open occluded regions in arteries. The procedure is relatively non-invasive, takes a very short time compared to by-pass surgery and the recovery time is minimal. However, it involves problems such as, elastic recoil of the stretched arterial wall, the re-clogging of the treated artery, formation of intimal fl aps or torn arterial linings which can collapse and occlude the blood conduit after the balloon is defl ated. To control these side eff ects, a stent may be implanted in the artery to keep the artery open. An alternative to a drug-delivery stent is a drug coated balloon (DCB). When the balloon is infl ated, and the balloon walls contact the vessel walls, the drug is released.


Topical Formulations


of Flucytosine; J. Qasem, R.H. Farmen, and K. Phelphs; U.S. Patent # 9,314,524; April 19, 2016.


Vulvovaginal candidiasis (VVC) is one of the most common conditions aff ecting women. Azole antifungal agents are used in complicated VVC. There have been reports of azole resistance in Candida species. Flucytosine, when given orally, has serious side-eff ects. One aspect of the present invention is to provide formulations of fl ucytosine in which the minimization of systemic absorption of the drug is controlled by careful choice of the nature and relative amount of excipient ingredients. Another aspect of the present invention is to provide fl ucytosine compositions for topical use, which retain therapeutically eff ective drug levels at the site of infection, so that the drug concentration is not depleted by systemic absorption and diff usion of the drug away from the site of application. In addition, the present invention provides formulations wherein the concentration of active drug is lower than had been previously considered eff ective.


www.americanpharmaceuticalreview.com |


| 71


»


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76