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CNPerspectives


American Pharmaceutical Review is one of several outstanding publications available from CompareNetworks, Inc. Here is a look at the insightful content our readers may enjoy from four of our sister publications: Pharmaceutical Outsourcing, American Laboratory, Labcompare, and Biocompare.


Implementation and Long-Term Maintenance of QbD Products in a Virtual Supply Chain


Implementation and long-term maintenance of Quality-by-Design (QbD) with a contract manufacturing organization (CMO) requires mutual in- depth knowledge of each other’s capabilities, quality systems and expectations. QbD requires thorough product understanding, data trending and analysis on an on-going basis as it relates to critical process parameters and quality attributes, analytical method performance and quality metrics; this brings additional challenges for both partners and as the industry moves towards higher volumes of data through continuous manufacturing, PAT and real-time release.


http://bit.ly/1rlGmjj


Getting the Complete Picture: How to Best Measure a Viscosity Flow Curve


This article focuses on the best way to measure flow curves to optimize value. A flow curve is a graphical representation of how the shear viscosity of a sample changes when it is subjected to different shear rates or shear stresses. Flow curves are often measured over a limited shear rate range, which can result in vital behaviors being overlooked as well as inadequate control of the product profile


http://bit.ly/1UvzKXs


Life Science Mass Spectrometry


How have the interactions of macromolecules in organisms evolved over eons? To find out, Cuihong Wan and Blake Borgeson—then both working at the Center for Systems and Synthetic Biology at the University of Texas at Austin—used various forms of mass spectrometry (MS) to study protein complexes across a wide range of organisms in search of protein–protein interactions that have endured as organisms evolved.


http://bit.ly/1Mqbf0i


Multiplexed Immunoassays


When it comes to detecting specific proteins in biological fluids, the gold standard is ELISA. The assay is fast, simple and high-throughput. What it is not, is multiplexed: A traditional ELISA quantifies one, and only one, analyte. Increasingly, however, researchers need more from their samples, especially when they’re handling precious samples, such as biopsies.


http://bit.ly/234SCmh www.americanpharmaceuticalreview.com | | 9


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