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Quality of life


that QoL, as assessed by the CAMPHOR questionnaire, had been able to predict clinical deterioration.20


Conclusions


What role functional endpoints play in the daily life of PAH patients is an important question. Based on the discussed considerations, we may conclude that several functional parameters (including 6MWT) are associated with parameters reflecting patients’ daily QoL. The assessment of QoL in PAH patients is of great value because QoL proved to be of prognostic relevance and it helps to determine minimal important clinical differences of functional tests. This facilitates the interpretation of their results and provides a connection to the daily life of patients. Clinically meaningful endpoints representing patients’ daily QoL, such as TTCW, are now used as primary endpoints of clinical trials, allowing real-life conclusions in clinical studies to be drawn. l


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