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Cystic fibrosis pocket guide Dosing


Child >1 month and adult: Loading dose: 10mg/kg (max. 400mg) every 12h for 3 doses, followed by maintenance dose 10mg/kg (max. 400mg) OD (dose may be increased according to levels – see comments)


Child >3 months: 25mg/kg (max. 2g) BD (extrapolated data) Adult: 2g BD


Adult: 1g BD Route Additional prescribing information IV


• Caution if hypersensitivity to vancomycin • Although no clear relationship between plasma concentration and toxicity, levels may be used to optimise treatment: trough concentration should be >10mg/l


IV


• May be useful for B. cepacia • P. aeruginosa is inherently resistant to temocillin


NEB


• Not licensed by this route • Reconstitute 1g vial with 3ml WFI


Child: 80mg/kg (max. 3.2g) TDS-QDS Adult: 3.2g TDS-QDS (max. 3.2g every 4 hours)


Child <18 years: safety and efficacy not established; however, if necessary in those >12 years: 1.5mg/kg (max. 100mg) as a single dose initially; then 1mg/ kg (max. 50mg) BD Adult: 100mg, followed by 50mg every 12 hours


IV –


IV


• Nausea appears to be particularly problematic in people with CF leading some centres to avoid loading dose – pre-medicating with anti-emetics can prevent treatment failure.


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