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Child > 1 month and adult: Under 60kg: 25 000 units/kg TDS; >60kg 2MU TDS Some centres use alternative dosing in adults: <40kg 1MU TDS; >40kg 2MU TDS
• Licensed for use in CF • Neurological events such as facial paraesthesia common in CF – reducing the dose (for example, to 1MU TDS in adults) may alleviate symptoms • Nephrotoxicity rare in CF when using standard doses
Route Additional prescribing information PO IV
• Antibiotic-associated colitis reported more frequently than with other antimicrobials – discontinue immediately if diarrhoea develops NB Max. dose in CF differs to manufacturers advice • Total daily IV dose may be given in 3 divided doses