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Mucolytics and modulation of airway surface liquid
This section includes several classes of drug with different modes of action. Hypertonic saline and mannitol act through rehydrating airway surface liquid and increasing mucociliary clearance.
alpha rhDnase (Pulmozyme®) (mucolytic enzyme)
rhDNase improves sputum rheology by cleaving DNA derived from human neutrophils. rhDNase remains a safe, well-established and effective treatment for patients with CF and should be considered first line.
Formulation Dosage Nebulised
Comments 2.5mg od
Enzymatically cleaves extra cellular DNA into shorter molecules. Used in the treatment of patients with mild, moderate and severe respiratory disease. Improves lung function, reduces exacerbations and has an anti- inflammatory effect. A formal challenge with pre-and post-lung function should be undertaken