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Cystic fibrosis pocket guide


Dosing


Acute DIOS Child: 10ml/kg/hour for 30 minutes, then 20ml/kg/hour for 30 minutes, then increase to 25ml/kg/hour if tolerated (max. 100ml/ kg or 4L (whichever is greater)) over 4 hours. Cycle may be repeated if required (max. 8L in 24h). Adult: 20–40 ml/kg/ hour up to a maximum of 1l/h over 8hours.


Recurrent DIOS/ chronic constipation As required per manufacturers instruction, for example, Movicol®


,


titrated according to response


Route Additional prescribing information PO


• The aim of treatment is to achieve fecal effluent consisting of clear fluid and resolution of pain, abdominal distension and vomiting


• Solution may be flavoured with clear fruit cordial to improve palatability. • Give orally or via NG


Domperidone or metoclopramide administered 30 minutes before initial dose may prevent abdominal distention and bloating


Abbreviations: BD=bis die, twice daily; CSCI=continuous subcutaneous infusion; INH=inhaled; INN=international nonproprietary name; IV=intravenous; MU=megaunit; NEB=nebulised; PO=per os, by mouth; QDS=quarta die sumendus, four times daily; TDS=ter die sumendus, three times daily


References on file www.hospitalpharmacyeurope.com 105


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