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Contents


Supplement Contents


Foreword 02 Foreword Dr G Dolan


Factor VIII products 03 Recombinant versus plasma products H Marijke van den Berg


05 Prophylaxis, pharmacokinetics, dosing and administration of factor VIII products Erik Berntorp


Haemophilia A and B 08 Haemophilia A and B Karin Fijnvandraat


Von Willebrand disease 11 Von Willebrand disease Pier Mannuccio Mannucci and Massimo Franchini


Rare bleeding disorders 14 Factor XI deficiency and other rare bleeding disorders Paula HB Bolton-Maggs


Inhibitor development 17 Inhibitor development and risk factors Samantha C Gouw


21 Treatment options following inhibitor development Christopher A Ludlam


Personalised treatment 25 Tailored and personalised approach to prophylaxis in patients with haemophilia A Cedric Hermans


Health economics 30 Health economics of factor VIII products Luciana Scalone, Lucia S D’Angiolella and Lorenzo G Mantovani


Editorial Consultant


Christine Clark PhD FRPharmS Editor, HPE


Editor-in-Chief Theresa Saklatvala PhD


Commissioning Editor Andrea Porter


Art Director Evelyn Bercott


Sales Director Neil Morris


General Manager Alex Beaumont


Copyright © Campden Publishing Limited 2013. The contents of this publication are protected by copyright. All rights reserved. No part of this publication may be produced, stored in a retrieval system or transmitted in any form or by any means without the written permission of the publisher. The views expressed in this publication are not necessarily those of the publisher or editorial advisors. While the publisher and editorial advisors have taken every care with regard to accuracy of editorial and advertisement contributions, they cannot be held responsible for any errors or omissions contained therein. Published in the United Kingdom by Campden Publishing Limited, 140, London Wall, London EC2Y 5DN, UK


Support for the editorial development of this handbook has been provided by Sobi.


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1 www.hospitalpharmacyeurope.com


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