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Drugs which people with long QT syndrome should avoid


Below is a list of the drugs that people with long QT syndrome should avoid. Please check with your GP and pharmacist if your doctor prescribes any new drugs for you, as this list may not be complete.


* = unlicensed, withdrawn or suspended in the UK market. Derived from Yap et al 1999, reports from www.qtdrugs.org up to January 2008, case reports from www.pubmed.com up to January 2008, the British National Formulary edition 54 at www.bnf.org.


Drug Group


Antiarrhythmics: Class I:


Class III:


Anti-anginals & vasodilators: Anti-hypertensives: Antihistamines:


Serotonin agonists &


antagonists: Antimicrobials: Macrolides:


Fluoroquinolones: Antifungals: Antimalarials: Others:


Psychiatric: Tricyclic


antidepressants: Serotonin reuptake Phenothiazines: Others:


Anti-cancer: Others:


thioridazine* chlorpromazine


haloperidol droperidol* sertindole arsenic trioxide


probucol domperidone levomethadyl* methadone


Avoid Completely


quinidine* procainamide disopyramide ajmaline* dihydroquinidine*


amiodarone sotalol d-sotalol* dofetilide* azimilide* ibutilide* sematilide* ersentilide* almokalant* nifekalant* terikalant* dronedarone*


prenylamine* terodiline* lidoflazine* bepridil* Vardenafil indapamide


terfenadine* astemizole* cisapride* ketanserin* dolasetron


erythromycin clarithromycin spiramycin sparfloxacin* moxifloxacin


nicardipine isradipine moexipril/hydrochlorthiazide ebastine* diphenhydramine


ondansetron, granisetron azithromycin roxithromycin* telithromycin


gatifloxacin* grepafloxacin* levofloxacin gemifloxacin* ofloxacin


ketoconazole fluconazole itraconazole voriconazole


chloroquine halofantrine* pentamidine quinine


foscarnet amantadine cotrimoxazole trimethoprim sulfa


amitriptyline nortriptyline desipramine*


clomipramine imipramine trimipramine doxepin trazodone protriptyline* amoxapine*


fluoxetine paroxetine venlafaxine sertraline zimeldine* citalopram


trifluoperazine prochlorperazine fluphenazine pimozide mesoridazine quetiapine


risperidone ziprasidone maprotiline lithium clozapine


tacrolimus tamoxifen geldanamycin* octreotide sunitib


vasopressin tizanidine alfuzosin amantidine


felbamate* fosphenytoin chloral hydrate organophosphates* galantamine solifenacin clobutinol* Perflutren lipid microspheres (echocardiographic contrast)


35 Cardiac Risk in the Young


Close Monitoring and Professional Supervision Required if Drug is Absolutely Necessary


flecainide propafenone pirmenol* cibenzoline* mexiletine


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