DermCom - to deliver the message for repair deep in the skin
Use of the skin’s own communication mechanism between epidermis and dermis for rejuvenation
C
osmetic products work at the skin’s surface. There, keratinocyte cells form the epidermis, the skin layer responsible for the barrier function. Another type of cells,
called fibroblast, build the underlying skin layer, called the dermis. Fibroblast cells produce the collagen and elastin fibres. The dermis is important for skin firmness and elasticity. Typical signs of skin ageing, like sagging and wrinkles, develop in the dermis. Fibroblasts of old skin can only synthesise collagen and elastin on a very reduced scale. Cosmetic ingredients can easily penetrate into the outer part of the epidermis but their access to the dermis is extremely limited. A strategy for the medication of the ageing dermis by cosmetic treatments could be to utilise the communication processes between the cells of the outer epidermis and the cells of the subjacent dermis. In this way, one could instruct fibroblast cells to activate the synthesis of collagen and elastin fibres.
after 24 hours after 72 hours
n Elastin 1230 473
n Lysyl oxidase-like 2 n CTGF 488 185
95 461
1400——————————————————————— 1200——————————————————————— 1000——————————————————————— 800——————————————————————— 600——————————————————————— 400——————————————————————— 200———————————————————————
0 ——————————————————————— after 24 hours
after 72 hours cell signalling growth factors
Epidermis – dermis communication is mediated by growth factors
Communication between epidermis and dermis is mediated by messenger compounds. The messengers are proteins, known as growth factors. They are released by keratinocytes and migrate by diffusion to fibroblasts where they bind to their receptors on the cell surface. The process is known as cell signalling. Depending on the nature of the messenger compound, they can induce specific reactions of the target cell. Cell signalling is a general process used by tissues to adapt to changes in the surroundings. The right active to correct the diminished formation of fibres in the dermis should trigger keratinocytes to release growth factors that communicate to fibroblasts to
epidermis
dermis
collagen and elastin
Gene expression in fibroblasts relative to control (%)
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