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Mind & Brain, the Journal of Psychiatry Table 1. Studies on Depressive Symptoms and Risk for Dementia


Follow-up dura-


Authors Study design


Naturalistic cohort study


tion(years) Sample type 3


Older primary care


population Edwards et al.25


Multicenter prospective longitudinal


11 Clinical population* 521 MCI ]50


No scale (only question based on DSM-111-R criteria for mental disorders)


Ravaglia et al.26 Prospective longitudinal Cherbuin et al.I5 Prospective longitudinal


Vicini Chiloyi et al.I8 Prospective cohort


2 4 4


Community- based


Community- based


Clinical population%


595 NCI 72 MCI


2082 NCI 124 MCI ]65 GDS-30 27


N and Dx at baseline


Association between depressive and apathetic symptoms and risk for dementia Boyle et al.I7


470 NCI


Age at baseline (years)


]65


Measures of affective symptoms


SCID HRS


Measures of congnition


MMSE Mattis-IP TMT-A & B


MMSE TMT-A & B WAIS-Block Desing & Digit Symbol


Category Fluency Wechsler Memory & Visual reproduction


MMSE Mental Deterioration Battery


6064 N/A


SF-I2 Goldberg Anxiety/ Depression scales


GDS-I5 NPI Hamilton Anxiety Scale


Prose memory test CDR


MMSE ADAS-Cog TMT-A&B RAVLT Novelli’s short story ROCF-copy


CFT-drawing Raven’s Colored Matrices Verbal Fluency (category & letter)


Palmer et al.28 Robert et al.I0


Multicenter (3) Prospective longitudinal


Multicenter (14) Pro- spective


longitudinal 4 3 Clinical Clinical population% population% I3I A-MCI 214 MCI


Mean70.8 (SD6.5)


]58 NPI


Goldberg Anxiety MADRS Apathy Inventory


MMSE Mental Deterioration Battery$


FCRST-16 items 29 BVRT Serial Digit Learning test WAIS Digit Symbol & similarities


TMT A & B Stroop test Verbal Fluency tasks (letter & category)


DENO 100 Dual Task of Baddeley


No association between depressive and apathetic symptoms and risk for dementia Ramakers et al.23


Prospective co- hort


Becker et al.20 Prospective


longitudinal and obser- vational


Mean5.4 Clinical population%


Mean7.1 Community- based


263 MCI 288 NCI 55 Mean77 HDRS CBS-D-10


MMSE Global deterioration scale BDS and other tests§


3-MSE


AMNART Raven’s Matrices CVLT BNT Verbal Fluency tasks Modified ROCF WAIS-RBlock Design (modified)


Digit Span TMTA Stroop test Dual Task of Baddeley Grooved Pegboard test


M&B 2011; 2:(1). July 2011


24


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