Lokmal®: Therapy is delivered over 3 days: morning
¦ is effective against all malaria parasites and afternoon.
in peripheral blood, including those
resistant to current therapies Therapy is delivered over 2 days: morning
¦ demonstrates significant benefits over and afternoon.
current antimalarial therapies:
In semi-immune patients in areas where
-very fast control of malaria symptoms, resistance to other antimalarials has
avoiding progression to cerebral malaria developed, use a 4-dose regimen given
-high cure rates (>96%) even in multi-drug over 2 days as oral first-line treatment.
resistance areas
-low recrudescence rates Therapy is delivered over 2 days: morning
-very good tolerability (better than that of and afternoon.
most competitors)
-easy fixed-dose combination regimen, Dosage schedule for small children and
simplifying compliance low-weight malaria patients.
-no requirement for a pre-treatment ECG as
there is no evidence of QTc prolongation In these patients, the timing of
and cardiotoxicity. administration of Lokmal® remains the
same, but both the 4-dose and the 6-dose
Prescribing Lokmal® regimen require adjustment for body
Lokmal® is for the treatment of malaria weight:
1patients (adults and children) in countries ¦ 5 to <15 kg 1 Lokmal tablet per dose
with endemic falciparum malaria. ¦ 15 to <25 kg 2Lokmal tablets per dose
Lokmal® is not for use as a prophylactic. ¦ 25 to <35 kg 3 Lokmal tablets per dose
¦ 35 kg and above, adult dose (4 tablets per
Lokmal® is presented as solid [Lokmal dose)
Caplet 80/480mg and Lokmal Tablet
20/120mg] and Lokmal Suspension. Administration and food
Although patients with acute malaria are
Adult dosage schedule frequently intolerant of food, Lokmal®
For adults (35 kg and above): should be taken with fluids (particularly
¦ In multi-drug resistant areas use a 6- drinks containing fats, such as milk) and
dose regimen, given over 3 days a s o r a l if possible, with a normal diet as soon as
first-line treatment. the patient can tolerate food.
Ingestion with fat-containing food and
drinks massively improves absorption.
BODY WEIGHT (AGE) CAPLETS TABLETS SUSPENSION Although any risk of recrudescence is very
Adult and 1 caplet to be small, patients who remain averse to food
Children > 35kg taken every
12 hours for during treatment should be closely (14 years and above)
3 days monitored.
3 tablets to be 25 - 35kg
taken every (9 - 13years)
12 hours for 3 days ARTEMETHER/LUMEFANTRINE
2 tablets to be 15 - 25kg
taken every Extracts from sweet wormwood, Artemisia
(4 - 8 years) 12 hours for 3 days annua, have been used for treating fevers in
5 - 15kg 1 tablet to be traditional Chinese medicine for some 2000
(1 - 3years) taken every
12 hours for 3 days years, under the name of Qinghaosu. In
5kg 7.5ml to be 1970, Chinese scientists isolated the active
taken once (1 - 3months)
daily for 3 days component, artemisinin, and developed it
10ml to be 7.5kg for the treatment of malaria.
taken once (4 -7months)
daily for 3 days
15ml to be 10.5kg Artemisinin derivatives
taken once
(8 - 12months) daily for 3 days Artemisinin is a sesquiterpene lactone
20ml to be containing a bridged endoperoxide. It has:
15kg (2-3yrs) taken once
daily for 3 days ¦ two main lipophilic derivatives,
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