coeliac watch
may be specific to the type of manifestation ie anti-TG2 in
12 Lo W, Sano K, Lebwohl B, Diamond B, Green PH. Changing presentation of adult celiac disease. Dig
Dis Sci. 2003 Feb;48(2):395-8
enteropathy, anti-TG3 in dermatitis herpetiformis and recently
13 Cranney A, Zarkadas M, Graham ID, Butzner JD, Rashid M, Warren R,et al. The Canadian Celiac
Health Survey. Dig Dis Sci. 2007 Apr;52(4):1087-95
anti-TG6 in patients with neurological manifestations (39). 14 Dickey W, Bodkin S. Prospective study of body mass index in patients with coeliac disease. BMJ. 1998
Nov 7;317(7168):1290
15 Dickey W. Body Mass Index in Celiac Disease: Beneficial Effect of a Gluten-free Diet. Am J Gastroen-
Conclusion
terol. 2006 Oct;101(10):2356-9
16 Cheng J, Brar PS, Lee AR, Green PH, J Clin Gastroenterol. 2009 Sep 23. [Epub ahead of print]
The data which we have presented may suggest that
17 Catassi C, Rätsch IM, Fabiani E, Rossini M, Bordicchia F, Candela F, et al. Coeliac disease in the year
2000: exploring the iceberg. Lancet. 1994 Jan 22;343(8891):200-3
there is a role for defining patients with gluten sensitivity and
18 Troncone R, Greco L, Mayer M, Paparo F, Caputo N, Micillo M, et al. Latent and potential coeliac
disease Acta Paediatr Suppl. 1996 May;412:10-4
acknowledging that these individuals are part of a spectrum 19 Matysiak-Budnik T, Malamut G, de Serre NP, Grosdidier E, Seguier S, Brousse N, et al. Long-term follow-
ranging from a an unaffected person (without coeliac dis-
up of 61 coeliac patients diagnosed in childhood: evolution toward latency is possible on a normal diet.
Gut. 2007 Oct;56(10):1379-86
ease) to a patient with coeliac disease. There may be benefit
20 Hopper AD, Hadjivassiliou M, Butt S, Sanders DS. Adult coeliac disease. BMJ. 2007 Sep 15;335(7619):558-62.
21 Sollid LM, Lundin KE. Diagnosis and treatment of celiac disease. Mucosal Immunol. 2009 Jan;2(1):3-7
in considering a GFD in these individuals who may present
22 Hopper AD, Hadjivassiliou M, Hurlstone DP, Lobo AJ, McAlindon ME, Egner W, et al. What is the role of
serologic testing in celiac disease? A prospective, biopsy-confirmed study with economic analysis. Clin
with both gastrointestinal and non-gastrointestinal manifesta-
Gastroenterol Hepatol. 2008 Mar;6(3):314-20
23 Mahadeva S, Wyatt JI, Howdle PD. Mahadeva S, Wyatt JI, Howdle PD. Is a raised intraepithelial
tions. It could be argued, for example, that whilst medica- lymphocyte count with normal duodenal villous architecture clinically relevant? J Clin Pathol. 2002
tions prescribed for IBS may have side effects, a GFD has no
Jun;55(6):424-8
24 Wahab PJ, Crusius JB, Meijer JW, Mulder CJ. Gluten challenge in borderline gluten-sensitive enteropa-
risk/side effect profile and may result in an improvement in
thy. Am J Gastroenterol. 2001 May;96(5):1464-9
25 Troncone R, Franzese A, Mazzarella G, Paparo F, Auricchio R, Coto I, et al. Gluten sensitivity in a subset
symptoms. Although the authors believe there is a role for
of children with insulin dependent diabetes mellitus. Am J Gastroenterol. 2003 Mar;98(3):590-5
26 Tursi A, Brandimarte G. The symptomatic and histologic response to a gluten-free diet in patients with
considering gluten sensitivity in clinical practice we would borderline enteropathy. J Clin Gastroenterol. 2003 Jan;36(1):13-7
27 Wahnschaffe U, Ullrich R, Riecken EO, Schulzke JD. Celiac disease-like abnormalities in a subgroup of
also wish to see further supportive data/research in the form patients with irritable bowel syndrome. Gastroenterology. 2001 Dec;121(6):1329-38
of multicentre randomised studies.
28 Humbert P, Pelletier F, Dreno B, Puzenat E, Aubin F. Gluten intolerance and skin diseases. Eur J Dermatol.
2006 Jan-Feb;16(1):4-11
References
29 Michaëlsson G, Gerdén B, Hagforsen E, Nilsson B, Pihl-Lundin I, Kraaz W, et al. Psoriasis patients with
1 Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving
antibodies to gliadin can be improved by a gluten-free diet. Br J Dermatol. 2000 Jan;142(1):44-51
spectrum. Gastroenterology. 2001 Feb;120(3):636-51
30 Hadjivassiliou M, Sanders DS, Grünewald RA, Woodroofe N, Boscolo S, Aeschlimann D. The neurology
2 West J, Logan RF, Hill PG, Lloyd A, Lewis S, Hubbard R, et al. Seroprevalence, correlates, and characteris-
of gluten sensitivity. Lancet Neurology (in press)
tics of undetected coeliac disease in England. Gut. 2003 Jul; 52(7):960-5
31 (Hadjivassiliou M, Davies-Jones GAB, Sanders DS, Grünewald RAG. Dietary treatment of gluten ataxia.
3 Sanders DS, Hurlstone DP, Stokes RO, Rashid F, Milford-Ward A, Hadjivassiliou M, et al. Changing face of J Neurol Neurosurg Psychiatry 2003;74(9):1221-1224)
adult coeliac disease: experience of a single university hospital in South Yorkshire. Postgrad Med J. 2002 32 Hadjivassiliou M, Grünewald RA, Kandler RH, Chattopadhyay AK, Jarratt JA, Sanders DS, et al. Neu-
Jan;78(915):31-3 ropathy associated with gluten sensitivity. J Neurol Neurosurg Psychiatry. 2006 Nov;77(11):1262-6
4 Johnston SD, Watson RG, McMillan SA, Sloan J, Love AH. Prevalence of coeliac disease in Northern 33 Hadjivassiliou M, Kandler RH, Chattopadhyay AK, Davies-Jones AG, Jarratt JA, Sanders DS, et al.
Ireland. Lancet. 1997 Nov 8;350(9088):1370 Dietary treatment of gluten neuropathy. Muscle Nerve. 2006 Dec;34(6):762-6
5 Mäki M, Mustalahti K, Kokkonen J, Kulmala P, Haapalahti M, Karttunen T, et al. Prevalence of Celiac 34 Hadjivassiliou M, Chattopadhyay AK, Grünewald RA, Jarratt JA, Kandler RH, et al. Myopathy associ-
disease among children in Finland. N Engl J Med. 2003 Jun 19;348(25):2517-24 ated with gluten sensitivity. Muscle Nerve. 2007 Apr;35(4):443-50
6 Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S, et al. Prevalence of celiac disease in at-risk and 35 Hadjivassiliou M, Grünewald RAG, Lawden M, Davies-Jones GAB, Powell T, Smith CML. Headache and
not-at-risk groups in the United States: a large multicenter study. Arch Intern Med. 2003 Feb 10;163(3):286-92 CNS white matter abnormalities associated with gluten sensitivity. Neurology 2001;56:385-388
7 Lohi S, Mustalahti K, Kaukinen K, Laurila K, Collin P, Rissanen H, et al. Increasing prevalence of coeliac 36 Korponay-Szabó IR, Halttunen T, Szalai Z, Laurila K, Király R, Kovács JB, et al. In vivo targeting of intestinal
disease over time. Aliment Pharmacol Ther. 2007 Nov 1;26(9):1217-25 and extraintestinal transglutaminase 2 by coeliac autoantibodies. Gut. 2004 May;53(5):641-8
8 van Heel DA, West J. Recent advances in coeliac disease. Gut. 2006 Jul;55(7):1037-46 37 Hadjivassiliou M, Mäki M, Sanders DS, Williamson CA, Grünewald RA, Woodroofe NM, et al.
9 Green PH. The many faces of celiac disease: clinical presentation of celiac disease in the adult popula- Autoantibody targeting of brain and intestinal transglutaminase in gluten ataxia. Neurology. 2006 Feb
tion. Gastroenterology. 2005 Apr;128(4 Suppl 1):S74-8 14;66(3):373-7
10 Zipser RD, Patel S, Yahya KZ, Baisch DW, Monarch E. Presentations of adult celiac disease in a nation- 38 Sárdy M, Kárpáti S, Merkl B, Paulsson M, Smyth N. Epidermal transglutaminase (TGase 3) is the autoanti-
wide patient support group. Dig Dis Sci. 2003 Apr;48(4):761-4 gen of dermatitis herpetiformis. J Exp Med. 2002 Mar 18;195(6):747-57
11 Ferguson A, Arranz E, O'Mahony S. Clinical and pathological spectrum of coeliac disease--active, 39 Hadjivassiliou M, Aeschlimann P, Strigun A, Sanders DS, Woodroofe N, Aeschlimann D. Autoantibodies
silent, latent, potential. Gut. 1993 Feb;34(2):150-1 in gluten ataxia recognise a novel neuronal transglutaminase. Annals of Neurology 2008;64:332-343
GLUTEN
WHEAT
FREE
FREE
Dedicated Wheat,
Gluten and Milk Free
manufacturing site
Conforms to new
ORGANIC BAKING MIXES & WHOLESOME PASTA Codex Guidelines
All ingredients and
finished goods tested
to Gluten <20ppm and
Total Milk <2.5ppm
PURE GLUTEN FREE PORRIDGE OATS &
Seal of Guarantee -
ORGANIC QUINOA, CORN & RICE CEREALS for your peace of mind
GLUTEN FREE
MINI BREADSTICKS
Traditionally gluten free food has relied on refi ned ingredients with poor
nutitional value like corn, rice and potato starches. We know how important
it is for coeliacs to have a nutritious diet so we’ve carefully chosen
wholesome ingredients like brown rice fl our, buckwheat and quinoa.
To find out more about our range of products
Cutt ing out wheat and gluten isn’t only for people with food allergies, it’s
visit our website or use contacts below
also a healthy way to keep your diet varied. Th at’s why our products are a
popular choice for coeliacs, healthy eaters and food lovers alike, plus they’re
www.lovemore-freefromfoods.com
suitable for vegetarians. email: lovemore@welshhills.com
W www.halenhearty.co.uk T 0207 616 8427 E hello@halenhearty.co.uk
Tel: 01685 813545
NHDmag.com Feb '10 - issue 51 29
4790 NHD.indd 1 21/01/2010 16:11
Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36