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oncolog-hematolog
ro
hematologie
Markeri imunohistochimici
cu potenţial rol prognostic
în limfoame maligne difuze
cu celule mari B
Smaranda Demian
1
, Emöke Horváth
2
, Z. Pávai,
G. Oltean
1
, I. Macarie
1
, Marcela Cândea
1
,
R. Demian
3
1. Universitatea de Medicină şi Farmacie Târgu-Mureş,
Clinica Medicală I Hematologie
2. Universitatea de Medicină şi Farmacie Târgu-Mureş,
Laborator de Anatomie Patologică
3. Universitatea de Medicină şi Farmacie Târgu-Mureş,
Clinica Oncologie
Adresa pentru corespondenţă:
Smaranda Demian
Spitalul Clinic de Urgenţă Tg. Mureş,
Clinica Medicală I, Tg. Mureş, Str. Gh. Marinescu nr. 50,
e-mail: smaranda_demian@yahoo.com
Abstract
Purpose: Diffuse large B-cell lymphomas Cases with expression of CD10, bcl6 or
(DLBCL) are biologically and clinically germinal center phenotype displayed
heterogenous. Immunohistochemistry better OS and FFS but logrank-test p
can be used not only for positive diagno- >0,05. Stage III or IV, IPI H/I or H, ECOG
sis but also for prognostic purpose. >/=2; high LDH, expression of bcl2, p53,
Patients and method: Tissue samples Ki67 >50% and activate B-cell(ABC)
from 28 DLBCL were included in tissue- phenotype were associated with worse
microarray construct and immunohis- OS and RFS, logrank p <0,05 at univari-
tochemically analysed, panel: CD79a, ate analysis. Applying Fischer’s exact
CD10, bcl2, bcl6, CD5, CD138, Ki67, p53, test, remission correlate positively with
CD44s and isoforms v3, v4, v5 and v6. CD10+, bcl6+, bcl2-, CD44v6 and non-
Results were correlated with classical ABC immunohistochemically assessed
prognostic factors and outcome (overall phenotype.
survival-OS and relapse-free survival- Conclusion: Immunohistochemistry re-
RFS). veal important prognostic information in
Results: CD44v6 was coexpressed with DLBCL. Tissue microarray technique is
bcl2 predominantly on bcl6 negative useful and labour costs profitable, for large
cases and correlated with advanced retrospective series studies especially.
stage, H/I or H-IPI, ECOG >/+2. CD44v3+ Keywords: large B-cell lymphoma, prog-
correlate with medular tumor invazion. nostic, immunohistochemistry
pag. 34
Nr. 7 (2)/2009
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