The Donald Danforth Plant Science Center is a
not-for-profit research institute with a global vision to
improve the human condition. Research at the
Danforth Center will enhance the nutritional content
of plants to improve human health, increase
agricultural production to create a sustainable
food supply, and provide the scientific ideas
and technologies that will contribute to the
economic growth of the St. Louis region
and of the State of Missouri.
Cover figure:
Understanding the mechanism for viral replication within plant cells is central to devising
a strategy to inhibit replication. Scientists in the Beachy lab are collaborating with the
Integrated Microscopy Facility to analyze tobacco mosaic virus replication using the high
depth resolution made possible by electron tomography. The cover image is a model of part
of a replication complex in a tobacco leaf cell. The image reveals extensive cross-bridging
(green profiles) between viral protein complexes (pink and blue profiles) and ribosomes
(red spheres), bound to the ER (white profile) or not associated with the ER. This ongoing
research aims at understanding how the cross-bridges relate to translation of viral proteins
on ribosomes, including identifying spatial distribution of viral proteins with respect to the
cross-bridges and other materials in such complexes.
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