Technology and product reviews cm2 /cm3
4,5 4
3,5 3
2,5 2
1,5 1
0,5 0
0 14 Figure 17: Mean (+SEM) change in wound size and volume over time.
negative, wound pain and exudate were reduced and healing was evident. While antimicrobial activity is generally
not the primary objective of clinical observations/consultations (this is reserved instead for research studies), experience in over 20 cases has so far revealed that Flaminal can have a positive effect on infected ulcers.
References 17 Van Den Plas D, De Smet K,
Sollie P. Improved Antimicrobial Peroxidase Compositions. 2006; Available at: http://www.wipo. int/patentscope/search/en/
WO2006133523 (accessed 2 March, 2012).
18 Bishop SM, Walker M, Rogers AA, Chen WY. Importance of
moisture balance at the wound- dressing interface. J Wound Care 2003; 12(4): 125–28.
Italian experience This was a single-centre, open-label case series investigating the efficacy of Flaminal in 23 patients with acute and chronic wounds of diverse aetiology (Table 2). Flaminal was applied in accordance with the manufacturer’s instructions and wounds were covered with secondary dressings. A scheduled treatment protocol was applied and patients were assessed at 14, 30 and 60 days. As shown in [Fig 17], this treatment facilitated a clear reduction in wound size and volume over time. It is also noteworthy that in four of the
pressure ulcer cases, healing was evident after just six days of treatment. Further analysis of healing progression is shown in [Fig 18], which illustrates a quantitative overview of the presence of epithelium, granulation, fibrin and necrosis for each wound type prior to treatment (week 0) and after two, four and eight weeks. The wounds began responding within two
weeks of treatment, with higher proportions of fibrin, granulation and epithelium
48 Wounds International Vol 3 | Issue 2 | ©Wounds International 2012
visible, as well as a lack of necrosis. [Fig 19] summarises how pain levels (visual analogue scale [VAS] evaluation) fluctuated before, during and after dressing change at the associated time points, suggesting a trend for a dampening of patient perceived pain over time — this effect may have contributed to the improved healing seen over time [Fig 17], or could have resulted from the healing and reduction in size. These quantifiable outcomes are
supplemented by feedback from the care givers: ‘Flaminal is very easy to use and provides the option to incorporate a second dressing of choice [the study incorporated non-adherent dressings and gauze but foams were most often used] — its presence beneath other dressings has not presented any issues. It demonstrates very good efficacy in
wounds with predominant Gram-positive organisms and compliance with Flaminal schedules has also been noted after one year in some cases’[4]
.
Classification and reimbursement — a French perspective The French perspective focused on the current reimbursement structure in France. Two classes of hydrogels are recognised at present — physical and chemical — and Flaminal falls into the later. Alginates are also a recognised category in the reimbursement of dressings in France — they vary according to carbohydrate
30 60
Surface Volume
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