Technology and product reviews T E C H N O L O G Y U P D A T E :


Expert consensus on a new enzyme alginogel


Flaminal® (Flen Pharma) products are alginate gels containing a novel antimicrobial enzyme system. They are designed to promote wound healing and to restore bacterial balance and their use on a wide range of wound types is supported by scientific and clinical evidence[1–4]


. Extensive clinical usage and trialling in Europe and Authors: Hilde Beele Corrado Durante


Jean-Charles Kerihuel Jan Rice


Armand Rondass Jan Stryja


Richard White


Australasia have provided an evidence base and a list of clinicians with an understanding of the clinical performance of Flaminal products. This expert panel reported that Flaminal products should be classified as ‘enzyme alginogels’ and identified four key functions — continuous wound debridement; antimicrobial activity; maintenance of a moist wound healing environment; and protection of wound edges and epithelial cells. These enzyme alginogels are compatible with the TIME framework, as demonstrated in the case histories. For example, like honey, they are one of the few materials said to have a number of modes of action[5]


wounds[6]


need for multiple products, for example, it has the capability to absorb excess exudate while remaining in a gelled state, promote debridement and control bioburden.


Useful links Antimicrobial dressings made easy I


t is widely appreciated that cellular and molecular imbalances in the wound bed can often delay healing[7]


FLAMINAL Flaminal®


. Models such as


the TIME framework — Tissue management, Inflammation and infection control, Moisture balance, Epithelial (edge) advancement — offer a logical and systematic approach to wound bed assessment[8,9]


. Table 1 summarises the disturbances in


wound bed remodelling associated with each stage of the TIME framework and the relevant treatment approaches. However, the clinical reality is that clinicians


often have to deal with several aspects of the TIME framework at the same time, which requires ongoing assessment and realignments in treatment, often using multiple products.


42 Wounds International Vol 3 | Issue 2 | ©Wounds International 2012 Hydro and Flaminal® Forte (Flen


Pharma) are the first items to become available in a new class of wound care products — the enzyme alginogels. They comprise hydrated alginate polymers in a polyethylene-glycol (PEG) matrix embedded with a patented antimicrobial enzymatic complex (GLG — glucose oxidase combined with lactoperoxidase, stabilised by guaiacol[1,10]


, however, unlike honey they do not sting when applied to . Furthermore, Flaminal’s triple mode of action avoids the


.


These naturally occurring enzymes are found in saliva and milk, and, as such, are important in the innate immune system. They have excellent biocompatibility with very limited, if any, likelihood of allergy (in the six-year life of the product, there has been one suspected allergic contact dermatitis and one irritant reaction).


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