Freelite®
Serum Free Light Chain Assays Suggested Laboratory Diagnostic Algorithm Nephrologists
General/Internal Medicine or Primary Care
Hematologists
Suspect
Monoclonal Gammopathy
Serum Protein Electrophoresis Serum Immunofixation
Serum Free Light Chain Assays (Free k, Free l and k/l ratio)
Add 24-h urine immunofixation if suspect AL amyloidosis
Abnormal Normal
Monoclonal band and/or
abnormal k/l ratio (Normal ratio: 0.26-1.65)
Perform
24-h urine protein electrophoresis and
immunofixation and continue work-up
<1% of monoclonal gammopathies.
Continue work-up (e.g. bone marrow biopsy) only with high clinical suspicion
An algorithm including Freelite will allow for the most sensitive and specific identification of all significant monoclonal proteins and negate the requirement for urine samples for screening for Bence Jones Protein, unless there is a strong clinical suspicion of AL amyloidosis.
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Freelite Clinical Information
Freelite Laboratory Information
Contact your local office
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