research round-up |
research round-up
INTENSE PULSED LIGHT FOR THE TREATMENT OF ROSACEA AND TELANGIECTASIAS
Kassir R, Kolluru A, Kassir M. J Cosmet Laser Ther 2011; 13(5): 216–22
the use of intense pulsed light (iPL) has shown significant clearing in erythema, telangiectasia, and papules in rosacea. We seek parameters for iPL that will achieve optimal reduction in the appearance of rosacea with minimal adverse effects. Objective: to investigate the use of iPL on 102 patients at various parameters (fluence and pulse duration) in the treatment of rosacea. Methods: 102 patients with mild to severe rosacea were treated with iPL treatment using the naturaLight iPL system (Focus Medical, Bethel, ct). Patients received treatments at 1–3 week intervals, with an average of 7.2 treatments. the Reveal imager (canfield scientific, Fairfield, nJ) was used for photodocumentation and analyses. Results: treatments were given at 2.5/5 ms double, triple, or quadruple pulsed with 20–30 ms delay time. a 530 nm filter was used with fluences varying from 10–30 J/cm2, or 10–20 J/cm2
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osacea is a chRonic disease that affects the aesthetic appearance of skin.
COST-EFFECTIVENESS OF RISK STRATIFICATION FOR PREVENTING TYPE 2 DIABETES USING A MULTI-MARKER DIABETES RISK SCORE
Sullivan SD, Garrison LP, Rinde H, Kolberg J, Moler EJ. J Med Econ 2011; 14(5): 609–16
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eRsonaLized Medicine RequiRes diagnostic tests that stratify patients into
with a 420 nm filter for those
patients with acneiform breakouts in addition to telangiectasias. 80% of patients had reduction in redness, 78% of patients reported reduced flushing and improved skin texture, and 72% noted fewer acneiform breakouts. there were no complications or adverse effects. Conclusion: the use of iPL at specified parameters provides optimal therapy for the treatment of rosacea.
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distinct groups that may differentially benefit from targeted treatment approaches. this study compared the costs and benefits of two approaches for identifying those at high risk of developing type 2 diabetes for entry into a diabetes prevention program. the first approach identified high risk patients using impaired fasting glucose (iFG). the second approach used the Predx diabetes Risk score (dRs) to further stratify iFG patients into high‑risk and moderate‑risk groups. Methods: a Markov model was developed to simulate the incidence and disease progression of diabetes and consequent costs and quality‑adjusted life expectancy (qaLY), comparing alternative approaches for identifying high‑risk patients. We modeled direct medical costs, including the costs of the stratification testing, over a 10‑year time horizon from a us payer perspective. Results: stratification of iFG patients by the dRs method leads to improved identification and prevention among those at highest risk. at 5 years, the number needed to treat (nnt) in the iFG‑only approach was 39 patients to prevent one case of diabetes compared to an nnt of 15 in the iFG + dRs approach. When compared to iFG alone, the iFG + dRs approach results in an incremental cost‑effectiveness ratio (iceR) of $17,100/qaLY gained at 5 years and would become cost saving in 10 years. in contrast and
November/December 2011 |
prime-journal.com
for the treatment of photoaging. Objective: to evaluate the efficacy and safety of Pdt using a novel 0.5% liposome‑encapsulated 5-aLa spray and an intense pulsed light (iPL) system (ellipse Flex PPt) in reduction of periorbital and nasolabial wrinkles. Patients and Methods: thirty healthy volunteers, aged 35–65 years, skin type i–iii, with type 2 photoaging underwent a baseline visit, three aLa-iPL treatments once every 3 weeks, an end‑of‑ treatment visit and a final visit 3 months after the end‑of‑treatment visit. Wrinkle depth was evaluated according to the modified Fitzpatrick wrinkle scale (MFWs). at the final visit, patients rated their degree of overall improvement. Results: For periorbital and nasolabial wrinkles, the differences of the
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as compared to no stratification, the iFG‑only approach would produce an iceR of $235,500/ qaLY gained at 5 years and $94,600/qaLY gained at 10 years. the study findings are limited by the generalizability of the dRs validation study and uncertainty regarding the long‑term effectiveness of diabetes prevention. Conclusions: the analysis indicates that the cost‑effectiveness of diabetes prevention can be improved by better identification of patients at highest risk for diabetes using the dRs.
EFFICACY AND TOLERABILITY OF 5-AMINOLEVULINIC ACID 0.5% LIPOSOMAL SPRAY AND INTENSE PULSED LIGHT IN WRINKLE REDUCTION OF PHOTODAMAGED SKIN
Piccioni A, Fargnoli MC, Schoinas S et al. J Dermatolog Treat 2011; 22(5): 247–53
hotodYnaMic theRaPY (Pdt) With 5‑aminolevulinic acid (5-aLa) is effective
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