| research report | ARTICLE


a statistical analysis of these results does not show


significance; therefore, conclusions with regard to the nature of these hydration effects cannot be made (P = 0.7). It is important to note, however, that the side-effects reported in the study were bruises of less than 1 cm2


Figure 12 Clinical aspect of treatment: (A) before, (B) after, and (C) 3 months later


(two


cases), and some post-treatment red patches which lasted for less than 1 hour. No nodular reactions, infections or pigmentation anomalies were reported. although the subject of this study is exclusively the


biometric evaluation, Figure 12 provides an idea of the clinical aspect. It would be profitable to extend this study to a greater number of cases. as it is merely an assessment of biometrological parameters, it ought to be completed by other research bearing on the comparative analysis of pictures as well as biologic and histological aspects.


Conclusions the study tracked 37 patients for a period of 3 weeks following prp treatment, and 27 for an additional 10 weeks post-prp treatment. a good anti-ageing effect was assessed by measured anisotropy values of -24.1% and -16.9%., respectively. additionally, a cross-analysis


References


1. Rosenthal AR, Harbury C, Egbert PR, Rubenstein E. Use of a platelet-fibrinogen- thrombin mixture as a corneal adhesive: experiments with sutureless lamellar keratoplasty in the rabbit. Invest Ophthalmol 1975; 14(11): 872–5


2. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998; 85(6): 638–46


3. Wieman TJ, Smiell JM, Su Y. Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers. A phase III randomized placebo-controlled double-blind study. Diabetes Care 1998; 21(5): 822–7


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690–4


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Effects of physical and chemical treatments upon biophysical properties and micro-relief of human skin. Arch Dermatol Res 2008; 300(5): 243–51


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prime-journal.com | November/December 2011 ❚ Key points


■ This study aimed to evaluate the efficacy of platelet rich plasma (PRP) treatment on facial skin through objective parameters


■ A good anti-ageing effect was assessed by measured anisotropy values of -24.1%. The initial anisotropy is validated as a predictor of the treatment efficacy


■ It can be concluded that PRP repairs more effectively, provided there is something to repair


involving the initial anisotropy readings demonstrated further improvement. the anisotropy correlates were -33% and -39.7%, respectively, if the treatment is provided to patients who would mostly benefit from it (anisotropy > 30%). the study also demonstrated that the effects of one prp treatment could last for up to 10 months. an additional predictor for a prp treatment was found to be the initial hydration status of the skin. Namely, post-treatment skin hydration was inversely proportional to the initial hydration. the objective criteria used in the study underscored


the ‘repair’ and ‘rejuvenation’ ability of the prp. therefore, it can be concluded that prp repairs more effectively, provided there is something to repair. those not in need of repair may use the treatment as an anti-ageing prophylactic.


Declaration of interest None of the authors of the above manuscript has declared any conflict of interest with either Kaylight Corporation or IntuiSkin.


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