ARTICLE | research report |
II Cell proliferation and matrix deposition
I Inflammation III Matrix remodelling
• Fibroplasia • Angiogenesis • Re-epithetialisation • Extracellular matrix synthesis
- Collagens - Fibronectin -Proteoglycans
• Bleeding • Coagulation • Platelet Activation • Complement Activation
0.1 0.3 1
• Granulocytes • Phagocytosis
• Macrophages • Cytokines
3 Figure 7 Phases of the wound healing process 10 Days after wounding 30 100 300
Extracellular matrix synthesis, degradation and remodelling Tensile strength Cellularity Vascularity
linear regression, while the significance between these tests, was determined when P < 0.05 (Visualstat software).
Figure 8 Age distribution (P<0.05) Figure 9 Anistropy distribution (P<0.05)
undergo any resurfacing applications (peeling, filling, laser, LeD, rF frequency) during the study.
Review of side-effects the questionnaire on side-effects checks for: ■ pain
■ Bruises ■ redness ■ oedema ■ pruritis ■ Granuloma ■ pigmentation ■ Unexpected side-effects.
Statistical analysis Quantitative variables were evaluated by calculating the mean and standard deviation. the comparison of the pre- and post-treatment mean was made using the student t-test for paired data. the correlation was evaluated via
36 ❚ November/December 2011 |
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Results and discussion Visit 1 thirty-seven female subjects were enrolled in the study, and were treated with prp. as a control group, two additional patients underwent full evaluation and received injections with saline rather than prp. the values of parameters at V1 between Day 21 (D21) and Day 28 (D28) were reported and were compared to the initial values (V0). they are expressed as a percentage variation (Figure 6). two parameters demonstrated meaningful improvement — anisotropy and teWL. the anisotropy significantly improved, showing a decrease of -6.98 points, so -24.1%. historically, this is a reliable value that relates to an
observable anti-ageing effect. subsequent improvement of the indicator was observed after a few months of treatment. this data was also observed over a short period (3 weeks) and is associated with an improvement in the micro-relief parameters with rt of -3.49% and length -3.15%. In parallel, the teWL indicator showed significant
improvement with a variance of -8.23%. this value correlates with the repair effect of prp treatments. specifically, the teWL is interpreted as a capacity of the skin to retain its water levels. the calorimetric parameters demonstrated only minor
improvement in luminance (up to +4.76%). other variations were minor and within the scale values set at 255 (r G B a b). No change was observed in skin temperature. the final evaluation point, hydration, showed reduced
levels at -6.07%. however, this dehydration proved transient and disappeared over the 3-month period.
Maximum response
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