| research report | ARTICLE
Using Objective criteria tO evalUate
cOsmetic effects Of Platelet rich Plasma
Gilbert Amgar, Christian Bonnet, Alain Butnaru and Fabienne Herault-Bardin discuss the results of a study which aimed to evaluate the efficacy of platelet rich plasma as a facial skin treatment
ABSTRACT Autologous platelet rich plasma (PRP) plays an important role in soft tissue healing. The purpose of this study was to evaluate the efficacy of this facial skin treatment through objective parameters. Biometric parameters, including anisotropy, transepidermal water loss (TEWL), micro-relief, and hydration were used to determine the relative success of the treatment. The study, which included 37 female patients, demonstrated an average of 24% improvement in the anisotropy coefficient after the third week. The TEWL and micro-relief parameters also improved significantly (P < 0.05 in all parameters tested). In addition to these results, this study suggests that certain measured values may be used to predict the success of the aesthetic use of PRP.
platelets as physiological adhesives in corneal surgery. since then, the literature has widely reported their functions and effects. a search in pubMed using the terms ‘platelet rich
H
plasma’ or ‘prp gel’ identifies more than 300 references. a search on Google results in over 300 000 links. the popularity of the platelet concentrate gel was further developed by Marks et al2
after demonstrating improved
osseous regeneration in dental surgery using prp. cutaneous repair was the domain which followed this interest, along with the evaluation of the platelet concentrate gel to heal the ulcers in diabetic patients3
a series of later publications focused on the vascular phenomena of cellular migration, collagen synthesis, and structural improvement. a number of publications have identified the range of platelet factors and their functions during the repair phenomena. a 1996 study demonstrated its impact on healing large-scale burns4
, and another important publication specified healing mechanisms when applied to wounds5
. this
allowed confirmation of the role of platelet factors and fibroblasts in these phenomena, as well as that of metalloprotease, fibrin, and fibronectin. subsequently, cosmetic surgery applications have been developed using prp as a ‘biological adhesive’6
IsToRICALLy, AuToLogous
platelet rich plasma (PRP) has been used for a variety of indications for more than 30 years, with effective results. The first publication on this subject, in 19751
the prp gel have been identified in orthopaedics7 cardiology8
, and rheumatology9, 10 . the use of prp in cosmetic surgery dates back to 2005.
the main indications include cutaneous regeneration, dark circles around the eyes11
, deals with the use of , and hair growth. In the case
of cutaneous revitalisation within cosmetology, only the subjective aspect has been traditionally evaluated based on the patient or physician’s subjective level of satisfaction. however, objective, scientifically measurable evaluations have been rare. one such case meta-analysis was published in 2007 by Borzini and Mazucco12
. .
Objectives of the study this study suggests a way to use biometric parameters to mitigate the lack of objective, scientifically measurable means of assessing the results from the use of prp injections, and to maximise its use by providing a means to qualify the most viable candidates prior to treatment.
. additional uses for ,
GILBERT AMGAR (MD), CHRISTIAN BONNET (MD), ALAIN BUTNARU (MD) and FABIENNE HERAULT-BARDIN (MD).
Gilbert Amgar is an aesthetic practitioner, DIU of ‘Médecine morphologique Anti Age’. He has advised and trained the staff of company specialising in autologous revitalisation, and chairs the Société Française de Self Regenerin.
email:
gilbert.amgar@
orange.fr
KEYWORDS platelet rich plasma, anisotropy, revitalisation, biometrics, facial skin, growth factors, MyCells
prime-journal.com | November/December 2011 ❚ 31
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