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cell population. so with this integral role that the skin plays in ageing, it was perhaps only a matter of
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almost identical to those found in embryos.
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time that researchers began to find methods of harvesting stem cells to aid repair and regeneration. Platelet rich plasma, for example, has been used for a while as a facial aesthetic treatment, which aids in the synthesis of collagen; and there is further research and product development underway in elastin-based therapy. however, two recent studies in stem cell research and the effect on ageing have
provided new breakthroughs in regenerative medicine. In the first study, researchers were successfully able to transform cells from patients as
Researchers were successfully able to transform cells from
patients as old as 100 into stem cells that were
old as 100 years of age into stem cells that were almost identical to those found in embryos. concerns were raised with regard to whether the technique could work effectively in older patients owing to the amount of deterioration already prominent in the cells of this patient cohort. however, by adding transcription factors to the method of generating adult stem cells, the researchers were able to overcome this challenge and ‘reset’ many of the key markers of ageing in cells. the second study to emerge in recent weeks perhaps went
even further, by actually ‘halting’ the ageing process in a laboratory environment. researchers in the Us have claimed that they have been able to
delay — and even eliminate — the onset of wrinkles, muscle wasting and cataracts in mice by ‘flushing out’ the cells that had stopped dividing. the scientists devised a way to kill all senescent cells in the mice, which had been genetically engineered for the study. the mice would age more quickly than usual, but when they were injected with a drug the senescent cells would die. this, in turn, would significantly delay the onset of three specific symptoms of old age: the formation of cataracts, the wasting of muscle tissue, and the loss of fat deposits under the skin. these two studies in particular, perhaps provide the most tantalising
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evidence for the future of aesthetic and anti-ageing medicine, with the great prospect of eventually slowing the ageing process in humans. however, as always, the process is slightly more complicated in humans and much more research is needed to verify the potential reality. It does remain, however, a fascinating time to be involved in this area of medicine
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Rosalind Hill managing editor, PRIME
rosalind.hill@informa.com;
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prime-journal.com | November/December 2011 Twitter LinkedIn Retweet ❚ 3
t cannot be denIed that stem cell scIence and research Is a fascinating area of anti-ageing medicine. and the ageing of the skin in particular is a complex area — it is affected by the ageing of all other bodily tissues. skin ageing involves an increased susceptibility to injury, infection, reduced wound healing, loss of dermal elasticity, poor epidermal barrier maintenance, wrinkling, hair-loss, and increased cancer risk. and the dermis itself plays a vital role in sustaining the stem
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