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Denise Wallworth Sigma-Aldrich and Honorary Secretary, The Chromatographic Society

organisation of nanoparticles, surface chirality and synthesis, nanoscale chirality in metals, including the use of gold nanoparticles for enantiomeric separations.

Developments in both racemisation techniques and preparative chiral chromatography mean that chiral chemistry no longer needs to produce 100% enantiomerically pure single isomers since the unwanted isomer can be racemised and re-processed, or simply ‘polished’ by chiral HPLC or SFC. However, chiral crystallisation also has a strong role to play in process development as it is often the most economic manufacturing solution; techniques for this will be discussed. Other critical chiral areas to be discussed include chiroptical techniques and properties, circular dichroism, green chemistry, novel chiral structures and drug design.


Liverpool, 2008 City Of Culture and birthplace of British music from the Beatles to a host of other 60’s bands, is the venue for Chirality 2011 this year. This meeting is hosted in Europe only every other year and, for all of those working in stereoisomer research, synthesis, separation and production of enantiomers, this is the essential conference for this year. Chirality 2011 is also known as ISCD 23, the International Symposium on Chiral Discrimination, and so the meeting provides a highly effective combination of asymmetric synthesis through to chiral separation techniques. Held July 10-13th in the Faculty of Medicine Sherrington Conference Centre of the University of Liverpool, the conference will of course also feature an iconic ‘Ferry across the Mersey’ conference dinner – not to be missed.

The Chromatographic Society will host two sessions in this Symposium – one on Advances in Chiral Chromatographic Techniques and one on issues associated with Chiral Bioanalysis. Pfizer (Fiona Harvey-Doyle) will provide a presentation on Stereochemical Challenges – how do you prove a negative? Zoe Cobb (Quotient Bioresearch) will highlight issues in drug metabolism for chiral molecules, using chiral HPLC to assess enantiomeric conversion in vivo. Chiral GC is often undervalued, primarily often because of the need for post-column preparative isolation, but GC offers many very fast and effective separations. Simon Hamilton (Novartis, UK) will discuss new and novel parallel method development techniques for chiral GC.

The Chirality Medal, instituted in 1991 by the Societa Chimica Italiana to honour internationally recognized scientists who have made a distinguished contribution to all aspects of chirality, is awarded this year to Professor Laurence Barron FRS, Emeritus Professor of Chemistry in the University of Glasgow. This award recognises his many contributions to fundamental and applied Chirality, in particular his work on electric, magnetic and optical properties of molecules and his research studies on Raman optical activity and other phenomena involving the interaction of polarized radiation with matter. The award will be made during the opening ceremony on Sunday, July 10th that will also include a presentation from Professor Barron.

Part of Chirality meeting will be the innovative ‘Chirality at the Nanoscale’ sessions. This will feature novel technologies, including the

Since no single chiral stationary phase (CSP) can separate all molecular types, the development of new phases is always welcome. There had been no significant developments since the launch of the versatile immobilised cellulosic and amylosic phases in 2004; this was followed by high efficiency 3µm versions of all the polysaccharide phases. Increased laboratory use of MS detection has resulted in

the increased use of MS compatible CSPs; macrocyclic glycopeptides, launched in 1994, have proven to be highly useful in such applications, where reversed and polar mobile phases are frequently chosen for optimum ionisation and sensitivity. Recently, Professor Daniel Armstrong (University at Texas Arlington) completed the development of a completely new range based on a cyclofructan chiral selector that appears to solve the elusive problem of the separation of chiral primary amines. There are always new challenges, such as the current increased use of natural products and synthetic molecules with multiple chiral centres as potential pharmaceutical therapies that will continue to push the boundaries of chiral chromatography.

Chirality 2011 addresses all of the key issues with presentations from leaders in throughout the field, including plenary speakers Chris Welch (MSD, US), Eric Francotte (Novartis, Basel) who both have lifetime experiences in chiral chromatography.

To view the programme and to register, please go to

Additional news is also continually being updated on the Chirality 2011 Facebook pages; Liverpool/159470074075187

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